Self-Powered Fontan Pump

Mark Rodefeld, MD

Indiana University

2023

We aim to carry out proof-of-concept feasibility studies for an implantable Fontan pump that is internally powered and does not require external energy. Current therapy for single ventricle heart disease is a Fontan circulation, which is palliative but not curative; all affected individuals will develop progressive circulatory failure and have shortened lifespans. A Fontan circulation is identical to a normal 2-ventricle circulation, except there is no right-side (subpulmonary) ventricle to pump blood through the lungs. A logical solution is to replace the missing pump to restore a normal circulation. However, implantable pumps are associated with adverse events and impaired quality of life due to dependence on external power and need for a power wire across the skin. To address these problems, we are innovating an implantable pump that uses an adjacent internal high-pressure energy source to power the low-pressure Fontan pump. Benefits include freedom from external power; no motor, wires, or batteries; no risk of percutaneous driveline infection or failure; self-regulating to rest or exercise; maintenance-free (other than blood thinners); lifetime service. Based on compelling preliminary data from computer modeling studies, we propose to build and test advanced prototypes in an in vitro Fontan mock circulatory loop. The findings will set the stage for NIH funding to carry out preclinical hemocompatibility development. The technology will have long-term impact on quality of life and lifespan of patients with single functional ventricle. Because of its simplicity, it will also have worldwide impact and expand access to Fontan repair in underserved populations.

This project was funded in part by the Haley Foundation.