FREE-BREATHING CINE DENSE MRI OF DYSSYNCHRONY AND DELAYED ACTIVATION IN PEDIATRIC SINGLE VENTRICLE PATIENTS

Doctor's Name: 
Cai, Xiaoying, BS
Hospital/Institution: 
University of Virginia

Collaboratively awarded through the CHF and AHA Congenital Heart Defect Research Awards

(Total Grant Amount $51,900; CHF portion = $25,950)

This proposal addresses the problem of how to assess and potentially improve treatment for patients who are born with single ventricle defects and who develop cardiac dysfunction, even after the reparative Fontan reconstruction operation. First, we propose to develop a free-breathing imaging method so that we can better image cardiac function in young subjects to quantify dyssynchronous contraction (dyssynchrony) and detect late-activating regions of the heart. Second, we propose to assess dyssynchrony and myocardial scar using the new imaging method along with the standard scar imaging protocol to investigate whether MRI can detect regions of the heart that are both late-activated and do not have scar. This study might demonstrate MRI as a powerful tool to optimize management and treatmen

First we would like to know the severity and prevalence of cardiac dyssynchrony in single ventricle patients. First, we will develop a repeatable free-breathing strain imaging method using advanced MRI engineering. Next we will apply this technique to image single ventricle patients and quantify dyssynchrony. By using imaging both strain and scar using MRI, we will determine whether single ventricle patients have locations in their hearts that are both late activating and free of scar, as such regions would be optimal target locations for implementing advanced pacemaker devices to resynchronize the heart and improve cardiac function.

The successful completion of this work will provide improved imaging methods to quantify cardiac dyssynchrony in young subjects and potentially lead to better therapies for patients who have undergone surgical repair of congenital heart disease

Award Date 1: 
2016
Award Amount 1: 
$25,950