In vitro studies of embryonic heart flows & fluid dynamics based on 3D models [TWO YEAR PROJECT]

Doctor's Name: 
David J. Sahn, MD
Hospital/Institution: 
Oregon Health and Science University

This is a study to develop accurate three dimensional (3D) computer models of the human embryo. Based on these computer models, plastic hand sized physical models will be constructed. These models will be used to study the dynamic process of how the heart shapes flow and how different flow patterns shape the heart. This will lead to better understanding of the different shear stress and/or pressure zones in the heart that trigger growth, molding and septation in the early stages of heart development. By understanding these, we will attain further knowledge on the initiators of the development (and hopefully, prevention) of congenital heart defects.

Award Date 1: 
1998
Award Amount 1: 
$75,000
Award Date 2: 
1999
Award Amount 2: 
$75,000