Tissue engineered pediatric cardiac valve replacement

Doctor's Name: 
Diane Hoffman—Kim, PhD
Brown Univ. School of Medicine

Using a sheep model, the investigators propose to design a "personal valve" containing cells derived only from the patient dwelling within a non-immunogenic cellular matrix support from a donor. Thus, the investigators hope to eliminate any need for immunosuppression, and at the same time provide a valve that can grow with the patient. Initially, they will develop an "optimal leaflet culture medium" that promotes growth of the tissue. They will develop a seeding protocol to introduce the growing cells into decellularized donor valves to create a living bioprosthetic valve replacement. Ultimately, they will develop criterion that will be used to evaluate how well the prosthesis resembles and approximates function of the native valve.

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