The role of neutrophil—derived factors in the pathogenesis of cardiac allograft vasculopathy

Doctor's Name: 
Kenneth O. Schowengerdt, MD
University of Florida College of Medicine

Dr. Schowengerdt and colleagues plan to test whether neutrophils can cause the abnormal growth of endothelial progenitor cells by examining this interaction in a culture dish. At present, it is not clear why certain transplant patients develop the coronary artery problem known as cardiac allograft vasculopathy (CAV) and why in some patients it is more rapidly progressive than in others. Recently, researchers have found that patients who are more likely to develop CAV may show differences in their bloodstream of a type of cell typically found in the lining of the blood vessels, the endothelial cell. Studies of adult heart transplant patients with CAV have shown that the earliest precursor forms of these cells, called endothelial cell progenitor cells may act differently or may be found in lower numbers than in heart transplant patients without CAV.

Understanding endothelial cell biology has become critical to understanding a number of heart-related diseases. Also, there is the possibility that the numbers and or quality of the endothelial cell pregnitors in the bloodstream may be markers for possible risk for developing CAV, which would be very useful information to the transplant physicians taking care of these patients in order to monitor and treat them.


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